Aplikace tiagabinu je spojená s neurochemickými a imunitními změnami a alterací chování v potkaním modelu deprese - olfaktorické bulbektomii.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00023354" target="_blank" >RIV/00216224:14110/07:00023354 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

Popis výsledku v původním jazyce

The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats chronically stressed by anosmia due to bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes (Leonard and Tuite, 1981). OB rats show significant increase in locomotor/exploratory activities in the open-field test, and altered plasma stress hormone levels and suppressed phagocytosis ofleukocytes what we have examined in the present experiments. After repeated tiagabine (12 mg/kg/day, IP) administration we measured the locomotor activity in the open-field test, adrenalin, noradrenaline, dopamine and corticosterone plasma levels and theleukocyte phagocytic function. Also the differential white blood cell counts were measured. Repeated tiagabine treatment elicited a significant decrease of the locomotor hyperactivity in the open field test. Taking into account that clin

Název v anglickém jazyce

Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression

Popis výsledku anglicky

The purpose of the study was to test a potential antidepressant effect of the 3rd generation antiepileptic tiagabine in rats chronically stressed by anosmia due to bilateral olfactory bulbectomy (OB), which is a well-established animal model of human depression resembling behavioural, immune and endocrine changes (Leonard and Tuite, 1981). OB rats show significant increase in locomotor/exploratory activities in the open-field test, and altered plasma stress hormone levels and suppressed phagocytosis ofleukocytes what we have examined in the present experiments. After repeated tiagabine (12 mg/kg/day, IP) administration we measured the locomotor activity in the open-field test, adrenalin, noradrenaline, dopamine and corticosterone plasma levels and theleukocyte phagocytic function. Also the differential white blood cell counts were measured. Repeated tiagabine treatment elicited a significant decrease of the locomotor hyperactivity in the open field test. Taking into account that clin

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmacopsychiatry

ISSN

0176-3679

e-ISSN

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Svazek periodika

2007

Číslo periodika v rámci svazku

40

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

1-6

Kód UT WoS článku

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EID výsledku v databázi Scopus

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