Modelling t-tubule function in cardiac ventricular myocytes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F07%3A00033625" target="_blank" >RIV/00216224:14110/07:00033625 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Modelling t-tubule function in cardiac ventricular myocytes

Popis výsledku v původním jazyce

Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape.

Název v anglickém jazyce

Modelling t-tubule function in cardiac ventricular myocytes

Popis výsledku anglicky

Cardiac transverse (t-) tubules form a complex network of membrane invaginations in mammalian ventricular myocytes, also known as the transverse-axial tubular system (TATS). Biophysically realistic computer models have been used to investigate experimental ambiguities and aspects of TATS function not currently amenable to experimental investigation: 1. Fraction of cell membrane within the TATS: Detubulation of rat ventricular myocytes causes a ~32% decrease of membrane capacitance whereas optical measurements suggest ~56% of the cell membrane within the TATS. Analysis of factors that may account for this discrepancy, and calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56%, suggest that the true fraction is at the upper end of this range. 2. Electrical coupling between the surface and TATS membranes: It has long been speculated that voltage control within the TATS may be inadequate, allowing voltage escape.

Druh

O - Ostatní výsledky

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů