Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F08%3A00033484" target="_blank" >RIV/00216224:14110/08:00033484 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
Popis výsledku v původním jazyce
Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important rolein the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestationalhypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus
Název v anglickém jazyce
Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and adiponectin genes?
Popis výsledku anglicky
Aim: The pathophysiology of pre-eclampsia, one of the leading causes of maternal mortality worldwide, still remains unclear. Recently, it has been suggested that impaired regulation of complex interactions among various adipokines plays an important rolein the development of pre-eclampsia. The aim of this study was to investigate whether the two common polymorphisms of the leptin (LEP) and adiponectin (APM1) genes are associated with the development of pre-eclampsia and its related traits (gestationalhypertension, proteinuria and various measures of reduced fetal growth) in the Czech pre-eclamptic population. Methods: The case-control study comprised a total of 123 pre-eclamptic women and 150 healthy controls of similar age and parity distribution. They were genotyped for the LEP -2548G/A (5-untranslated region) and APM1 T94G (exon 2) polymorphisms using polymerase chain reaction. Results: The allele frequency of the LEP -2548G polymorphism was 0.541 in the pre-eclamptic group versus
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2008
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
The Journal of Obstetrics and Gynaecology Research
ISSN
1341-8076
e-ISSN
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Svazek periodika
2008
Číslo periodika v rámci svazku
XX
Stát vydavatele periodika
JP - Japonsko
Počet stran výsledku
8
Strana od-do
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Kód UT WoS článku
000259270800014
EID výsledku v databázi Scopus
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