Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F09%3A00029671" target="_blank" >RIV/00216224:14110/09:00029671 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
Popis výsledku v původním jazyce
The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ionic channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known toprolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models, mainly after its acute administration. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomollar concentration of haloperidol. Hearts from both untreated and chronicallyto haloperidol exposed animals were investigated.
Název v anglickém jazyce
Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
Popis výsledku anglicky
The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ionic channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known toprolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models, mainly after its acute administration. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomollar concentration of haloperidol. Hearts from both untreated and chronicallyto haloperidol exposed animals were investigated.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA102%2F07%2F1473" target="_blank" >GA102/07/1473: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2009
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Canadian Journal of Physiology and Pharmacology
ISSN
1205-7541
e-ISSN
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Svazek periodika
87
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
CA - Kanada
Počet stran výsledku
9
Strana od-do
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Kód UT WoS článku
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EID výsledku v databázi Scopus
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