Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00043491" target="_blank" >RIV/00216224:14110/10:00043491 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Popis výsledku v původním jazyce

There is a growing evidence that cytokines act as crucial signaling molecules for response of peripheral nerves to injury. We studied levels of tumor necrosis factor alpha (TNF-a) and interleukin 10 (IL-10) proteins using ELISA in the ipsi- and contralateral lumbar and cervical dorsal root ganglia (DRG) from naive rats, rats operated for unilateral chronic constriction injury (CCI) of the sciatic nerve, and sham-operated rats. The ipsilateral hind paws of all operated rats displayed decreased withdrawalthresholds for mechanical allodynia and thermal hyperalgesia, while no significant changes were found in the contralateral hind paws and both forepaws. Bilateral elevation of TNF-a and IL-10 protein was induced in both the lumbar and cervical DRG not only in the homonymous DRG but also in the DRG unassociated with the injured nerve.

Název v anglickém jazyce

Bilateral changes of TNF-alpha and IL-10 protein in the lumbar and cervical dorsal root ganglia following a unilateral chronic constriction injury of the sciatic nerve

Popis výsledku anglicky

There is a growing evidence that cytokines act as crucial signaling molecules for response of peripheral nerves to injury. We studied levels of tumor necrosis factor alpha (TNF-a) and interleukin 10 (IL-10) proteins using ELISA in the ipsi- and contralateral lumbar and cervical dorsal root ganglia (DRG) from naive rats, rats operated for unilateral chronic constriction injury (CCI) of the sciatic nerve, and sham-operated rats. The ipsilateral hind paws of all operated rats displayed decreased withdrawalthresholds for mechanical allodynia and thermal hyperalgesia, while no significant changes were found in the contralateral hind paws and both forepaws. Bilateral elevation of TNF-a and IL-10 protein was induced in both the lumbar and cervical DRG not only in the homonymous DRG but also in the DRG unassociated with the injured nerve.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/GA309%2F07%2F0121" target="_blank" >GA309/07/0121: Změny cytokinů ve spinálních gangliích experimentálních modelů neuropatické bolesti indukované unilaterálním poškozením nervu</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of neuroinflammation

ISSN

1742-2094

e-ISSN

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Svazek periodika

7/2010

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000274831200001

EID výsledku v databázi Scopus

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