Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00044686" target="_blank" >RIV/00216224:14110/10:00044686 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/10:00003114

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

Popis výsledku v původním jazyce

The aim of this work was to study the distribution of heavy metals and of subsequently developed morphological changes in the liver of female mice and their foetuses after oral administration of high doses of lead, mercury, and cadmium (0.03 mg of metalper mouse and day). Heavy metals were administered to pregnant female mice on days 9 to 20 of pregnancy. The animals were euthanised by cervical dislocation. Samples of mother and foetal liver were subsequently collected and processed by means of the common technique for light and electron microscopy. Histochemical reaction based on metal conversion into appropriate sulphide that conjugates with silver was used for detection of heavy metals. Deposits of heavy metals were found at the periphery of lobules of the central vein in the liver of female mice. On the contrary, in the liver of foetuses no predilection site for localisation of the reaction product could be identified.

Název v anglickém jazyce

Distribution of Heavy Metals in the Liver of Foetuses and Female Mice after Oral Administration during Pregnancy, a Histochemical Study

Popis výsledku anglicky

The aim of this work was to study the distribution of heavy metals and of subsequently developed morphological changes in the liver of female mice and their foetuses after oral administration of high doses of lead, mercury, and cadmium (0.03 mg of metalper mouse and day). Heavy metals were administered to pregnant female mice on days 9 to 20 of pregnancy. The animals were euthanised by cervical dislocation. Samples of mother and foetal liver were subsequently collected and processed by means of the common technique for light and electron microscopy. Histochemical reaction based on metal conversion into appropriate sulphide that conjugates with silver was used for detection of heavy metals. Deposits of heavy metals were found at the periphery of lobules of the central vein in the liver of female mice. On the contrary, in the liver of foetuses no predilection site for localisation of the reaction product could be identified.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Veterinaria

ISSN

0001-7213

e-ISSN

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Svazek periodika

2010

Číslo periodika v rámci svazku

79

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000280221700008

EID výsledku v databázi Scopus

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