The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00045035" target="_blank" >RIV/00216224:14110/10:00045035 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/10:#0001080

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

Popis výsledku v původním jazyce

Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L(12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.

Název v anglickém jazyce

The Effects of Lidocaine on Bupivacaine-Induced Cardiotoxicity in the Isolated Rat Heart

Popis výsledku anglicky

Bupivacaine is a widely used long-acting local anaesthetic. The aim of this study was to compare the cardiotoxicity of large doses of bupivacaine and mixture of bupivacaine with lidocaine in the isolated rat heart and to estimate whether or not the addition of lidocaine in clinically relevant concentration increases bupivacaine-induced toxicity. Experiments were performed on 21 adult male rats divided into three groups: B (6 mu g/ml bupivacaine), BL (6 mu g/ml bupivacaine and 12 mu g/ml lidocaine) and L(12 mu g/ml lidocaine). The isolated hearts were perfused according to Langendorff with Krebs-Henseleit solution at constant pressure and the heart rate, PQ and QRS intervals were measured. The present study shows that the mixture of tested local anaesthetics - bupivacaine and lidocaine - impairs the intraventricular conduction parameters (QRS interval prolongation) to a lesser extent than bupivacaine itself, and that this effect is marked mainly at the beginning of perfusion.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA102%2F07%2F1473" target="_blank" >GA102/07/1473: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

59

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000279049100010

EID výsledku v databázi Scopus

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