Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00046981" target="_blank" >RIV/00216224:14110/10:00046981 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/10:00003017

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

Popis výsledku v původním jazyce

Introduction: The aim of the study was to compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). Methods: We modified a previously published rabbit model of arterial thrombosis prevention to compare UFHand two different doses of two LMWH fragments - nadroparin and enoxaparin. Thrombosis was triggered by vessel wall injury and critical stenosis. Blood flow monitored by a flow probe. The primary endpoints were: cumulative flow, time to occlusion and residual clot weight. Thirty six animals were split into 6 groups. Control groups were given saline or UFH and four more groups were used to compare LMWH's at 2 different doses. Results: In our study, all treatments were superior to the saline control group.UFH was inferior to both LMWH's for all primary endpoints. There were no differences between the LMWH's except for cumulative flow at high doses. Conclusions: This study revealed no relevant differences between nadroparin and enoxaparin.

Název v anglickém jazyce

Direct comparison of enoxaparin and nadroparin in a rabbit model of arterial thrombosis prevention

Popis výsledku anglicky

Introduction: The aim of the study was to compare the efficacy of standard unfractionated heparin (UFH) and low-molecular weight heparins (LMWH's). Methods: We modified a previously published rabbit model of arterial thrombosis prevention to compare UFHand two different doses of two LMWH fragments - nadroparin and enoxaparin. Thrombosis was triggered by vessel wall injury and critical stenosis. Blood flow monitored by a flow probe. The primary endpoints were: cumulative flow, time to occlusion and residual clot weight. Thirty six animals were split into 6 groups. Control groups were given saline or UFH and four more groups were used to compare LMWH's at 2 different doses. Results: In our study, all treatments were superior to the saline control group.UFH was inferior to both LMWH's for all primary endpoints. There were no differences between the LMWH's except for cumulative flow at high doses. Conclusions: This study revealed no relevant differences between nadroparin and enoxaparin.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Thrombosis Research

ISSN

0049-3848

e-ISSN

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Svazek periodika

126

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000278654600012

EID výsledku v databázi Scopus

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