Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F10%3A00051810" target="_blank" >RIV/00216224:14110/10:00051810 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00209805:_____/10:#0000250

Výsledek na webu

<a href="http://dx.doi.org/10.1136/oem.2009.046839" target="_blank" >http://dx.doi.org/10.1136/oem.2009.046839</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1136/oem.2009.046839" target="_blank" >10.1136/oem.2009.046839</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study

Popis výsledku v původním jazyce

To investigate the role of occupational exposure to organic solvents in the aetiology of B-cell non-Hodgkin's lymphoma (B-NHL) and its major subtypes, as well as Hodgkin's lymphoma and T-cell lymphoma. Methods 2348 lymphoma cases and 2462 controls participated in a case-control study in six European countries. A subset of cases were reviewed by a panel of pathologists to ensure diagnostic consistency. Exposure to solvents was assessed by industrial hygienists and occupational experts based on a detailedoccupational questionnaire. Results Risk of follicular lymphoma significantly increased with three independent metrics of exposure to benzene, toluene and xylene (BTX) (combined p = 4 x 10(-7)) and to styrene (p = 1 x 10(-5)), and chronic lymphocytic leukaemia (CLL) risk increased with exposure to solvents overall (p = 4 x 10(-6)), BTX (p = 5 x 10(-5)), gasoline (p = 8 x 10(-5)) and other solvents (p = 2 x 10(-6)). Risk of B-NHL for ever exposure to solvents was not elevated (OR = 1.1,

Název v anglickém jazyce

Occupational exposure to solvents and risk of lymphoma subtypes: results from the Epilymph case-control study

Popis výsledku anglicky

To investigate the role of occupational exposure to organic solvents in the aetiology of B-cell non-Hodgkin's lymphoma (B-NHL) and its major subtypes, as well as Hodgkin's lymphoma and T-cell lymphoma. Methods 2348 lymphoma cases and 2462 controls participated in a case-control study in six European countries. A subset of cases were reviewed by a panel of pathologists to ensure diagnostic consistency. Exposure to solvents was assessed by industrial hygienists and occupational experts based on a detailedoccupational questionnaire. Results Risk of follicular lymphoma significantly increased with three independent metrics of exposure to benzene, toluene and xylene (BTX) (combined p = 4 x 10(-7)) and to styrene (p = 1 x 10(-5)), and chronic lymphocytic leukaemia (CLL) risk increased with exposure to solvents overall (p = 4 x 10(-6)), BTX (p = 5 x 10(-5)), gasoline (p = 8 x 10(-5)) and other solvents (p = 2 x 10(-6)). Risk of B-NHL for ever exposure to solvents was not elevated (OR = 1.1,

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Occupational and environmental medicine

ISSN

1351-0711

e-ISSN

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Svazek periodika

67

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

341-347

Kód UT WoS článku

000277383300012

EID výsledku v databázi Scopus

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