Effect of perphenazine on electrogram of rat isolated heart
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00049756" target="_blank" >RIV/00216224:14110/11:00049756 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.2754/avb201180010087" target="_blank" >http://dx.doi.org/10.2754/avb201180010087</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2754/avb201180010087" target="_blank" >10.2754/avb201180010087</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effect of perphenazine on electrogram of rat isolated heart
Popis výsledku v původním jazyce
The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidenceof arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significa
Název v anglickém jazyce
Effect of perphenazine on electrogram of rat isolated heart
Popis výsledku anglicky
The aim of this study was to clarify whether administration of antipsychotic perphenazine contributes to the electrophysiological changes of the isolated heart. Fourteen adult male Wistar rats were divided into two groups. Langendorff hearts were perfused with Krebs-Henseleit solution at constant pressure (85 mmHg). The electrogram was recorded by touch-free method. The hearts of the first group were exposed to 3.10-5 M perphenazine, the hearts of the second group to 3.10-8 M perphenazine. The incidenceof arrhythmias and the heart rate and QT interval changes were studied on electrogram during 30 min periods of control, the first perphenazine administration, washout, and the second drug administration. Perphenazine administration significantly prolonged QT and QTc in group 1. In group 2, QT and QTc prolongation was less pronounced. A number of arrhythmias appeared, from single premature ventricular complexes to more severe ones in both groups. The heart rate changes were non-significa
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA102%2F07%2F1473" target="_blank" >GA102/07/1473: Optické metody registrace elektrických potenciálů a koncentrace vápníku v srdci s laserovou stabilizací</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Veterinaria Brno
ISSN
0001-7213
e-ISSN
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Svazek periodika
80
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
6
Strana od-do
87-92
Kód UT WoS článku
000289532200012
EID výsledku v databázi Scopus
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