Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00051442" target="_blank" >RIV/00216224:14110/11:00051442 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/11:#0000644

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.archoralbio.2010.09.005" target="_blank" >http://dx.doi.org/10.1016/j.archoralbio.2010.09.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.archoralbio.2010.09.005" target="_blank" >10.1016/j.archoralbio.2010.09.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria

Popis výsledku v původním jazyce

Interferon gamma (IFN-gamma) is one of the key regulatory cytokines that has a significant effect on immune responses. It may be important in the chronic inflammatory diseases such as periodontitis in which increased IFN-gamma levels were found. The aimof this study was to analyze +874A/T polymorphism in the IFN-gamma gene and its associations with the presence of periodontopathic bacteria and susceptibility to generalized chronic periodontitis (CP). Our results showed no differences in the allele andgenotype frequencies of the IFN-gamma +874A/T polymorphism between patients with CP and controls (p&lt;0.05). Although we found significant differences in the occurrence of periodontal bacteria between patients with CP and healthy controls (from p&lt;0.00001 to p&lt;0.05), no significant association between IFN-gamma +874A/T polymorphism and periodontal pathogens was observed in any group.

Název v anglickém jazyce

Interferon-gamma +874A/T polymorphism in relation to generalized chronic periodontitis and the presence of periodontopathic bacteria

Popis výsledku anglicky

Interferon gamma (IFN-gamma) is one of the key regulatory cytokines that has a significant effect on immune responses. It may be important in the chronic inflammatory diseases such as periodontitis in which increased IFN-gamma levels were found. The aimof this study was to analyze +874A/T polymorphism in the IFN-gamma gene and its associations with the presence of periodontopathic bacteria and susceptibility to generalized chronic periodontitis (CP). Our results showed no differences in the allele andgenotype frequencies of the IFN-gamma +874A/T polymorphism between patients with CP and controls (p&lt;0.05). Although we found significant differences in the occurrence of periodontal bacteria between patients with CP and healthy controls (from p&lt;0.00001 to p&lt;0.05), no significant association between IFN-gamma +874A/T polymorphism and periodontal pathogens was observed in any group.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Oral Biology

ISSN

0003-9969

e-ISSN

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Svazek periodika

56

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

153-158

Kód UT WoS článku

000287465500007

EID výsledku v databázi Scopus

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