Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00053051" target="_blank" >RIV/00216224:14110/11:00053051 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aanat.2011.02.011" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2011.02.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aanat.2011.02.011" target="_blank" >10.1016/j.aanat.2011.02.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

Popis výsledku v původním jazyce

Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres. These events consist of cellular and molecular alterations, including macrophage invasion, activation of Schwann cells, as well as neurotrophin and cytokine upregulation. This review focuses on cellular and molecular changes distal to various types of peripheral nerve injury which simultaneously contribute to axonal regeneration and neuropathic pain induction. In addition to the stereotypical events of Wallerian degeneration, various types of nerve damage provide different conditions for both axonal regeneration and neuropathic pain induction. Wallerian degeneration of injured peripheral nerve is associated with an inflammatory response including rapid upregulation of the immune signal molecules like cytokines, chemokines and transcription factors with both beneficial and detrimental effects on nerve regeneration or neuropathic pain induction.

Název v anglickém jazyce

Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction

Popis výsledku anglicky

Wallerian degeneration is a cascade of stereotypical events in reaction to injury of nerve fibres. These events consist of cellular and molecular alterations, including macrophage invasion, activation of Schwann cells, as well as neurotrophin and cytokine upregulation. This review focuses on cellular and molecular changes distal to various types of peripheral nerve injury which simultaneously contribute to axonal regeneration and neuropathic pain induction. In addition to the stereotypical events of Wallerian degeneration, various types of nerve damage provide different conditions for both axonal regeneration and neuropathic pain induction. Wallerian degeneration of injured peripheral nerve is associated with an inflammatory response including rapid upregulation of the immune signal molecules like cytokines, chemokines and transcription factors with both beneficial and detrimental effects on nerve regeneration or neuropathic pain induction.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Anatomy

ISSN

0940-9602

e-ISSN

—

Svazek periodika

193

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

267-275

Kód UT WoS článku

000294520800004

EID výsledku v databázi Scopus

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