The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00053159" target="_blank" >RIV/00216224:14110/11:00053159 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s12311-010-0237-y" target="_blank" >http://dx.doi.org/10.1007/s12311-010-0237-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s12311-010-0237-y" target="_blank" >10.1007/s12311-010-0237-y</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia
Popis výsledku v původním jazyce
The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas.
Název v anglickém jazyce
The Neural Substrate of Predictive Motor Timing in Spinocerebellar Ataxia
Popis výsledku anglicky
The neural mechanisms involved in motor timing are subcortical, involving mainly cerebellum and basal ganglia. However, the role played by these structures in predictive motor timing is not well understood. Unlike motor timing, which is often tested using rhythm production tasks, predictive motor timing requires visuo-motor coordination in anticipation of a future event, and it is evident in behaviors such as catching a ball or shooting a moving target. We examined the role of the cerebellum and striatum in predictive motor timing in a target interception task in healthy (n = 12) individuals and in subjects (n = 9) with spinocerebellar ataxia types 6 and 8. The performance of the healthy subjects was better than that of the spinocerebellar ataxia. Successful performance in both groups was associated with increased activity in the cerebellum (right dentate nucleus, left uvula (lobule V), and lobule VI), thalamus, and in several cortical areas.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FH - Neurologie, neurochirurgie, neurovědy
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Cerebellum
ISSN
1473-4222
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
12
Strana od-do
233-244
Kód UT WoS článku
000291601100008
EID výsledku v databázi Scopus
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