No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00054111" target="_blank" >RIV/00216224:14110/11:00054111 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61383082:_____/11:0071 RIV/00216208:11110/11:9771 RIV/00064165:_____/11:9771

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Popis výsledku v původním jazyce

Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect of promotervariations of HMOX1 andUGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). Material and methods. The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)nand (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patientsand a control group (p &gt; 0.05). Furthermore, no association was detected (p &gt; 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients.

Název v anglickém jazyce

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Popis výsledku anglicky

Background. Heme oxygenase-1 (HMOX1) and bilirubin UDP-glucuronosyltransferase (UGT1A1), both enzymes involved in bilirubin homeostasis, play an important role inoxidative stress defense. Objective. To assess the effect of promotervariations of HMOX1 andUGT1A1 genes on the progression of fibrosis in patients chronically infected with the hepatitis C virus (HCV). Material and methods. The study was performed on146 chronic HCV infection patients, plus 146 age- and sex-matched healthy subjects. The (GT)nand (TA)n dinucleotide variations in HMOX1 and UGT1A1 gene promoters, respectively, were determined by fragment analysis in all subjects. Results. No differences were found in the frequencies of each particular allele of both genes, between HCV patientsand a control group (p &gt; 0.05). Furthermore, no association was detected (p &gt; 0.05) between either the HMOX1 or the UGT1A1 promoter variants and the individual histological stages of liver disease in the HCV positive patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

<a href="/cs/project/NR9412" target="_blank" >NR9412: Role hemoxygenázy v patogenezi jaterního poškození u chronické HCV infekce</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Hepatology

ISSN

1665-2681

e-ISSN

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Svazek periodika

10

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

MX - Spojené státy mexické

Počet stran výsledku

7

Strana od-do

445-451

Kód UT WoS článku

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EID výsledku v databázi Scopus

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