Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055096" target="_blank" >RIV/00216224:14110/11:00055096 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/65269705:_____/11:#0001507 RIV/00209805:_____/11:#0000182
Výsledek na webu
<a href="http://dx.doi.org/10.4149/neo_2011_05_377" target="_blank" >http://dx.doi.org/10.4149/neo_2011_05_377</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2011_05_377" target="_blank" >10.4149/neo_2011_05_377</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
Popis výsledku v původním jazyce
Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels ofPAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025).
Název v anglickém jazyce
Clinical significance of the plasminogen activator system in relation to grade of tumor and treatment response in colorectal carcinoma patients
Popis výsledku anglicky
Urokinase (uPA) plays an essential role in the activation of plasminogen to plasmin, and together with its receptor (uPAR), tissue activator (tPA) and urokinase inhibitors (PAI 1, PAI 2, PAI 3 and protease nexin) forms the plasminogen activator system (PAS), a component of metastatic cascade importantly contributing to the invasive growth and angiogenesis of malignant tumours. In our project we examined the expression of uPA, uPAR, PAI 1 and PAI 2 in tumor tissue and we also studied the plasma levels ofPAI 1 before and after the initiation of therapy in patients with colorectal carcinoma in relationship to grade of tumor and the treatment response. In our prospective evaluation we included 80 patients treated for adenocarcinoma of the colon and rectum. Analysis of collected data revealed statistically significant evidence of a relationship between the level of PAI 1 in plasma before treatment and grade of the tumor, which increases with tumor grade (p=0.025).
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neoplasma
ISSN
0028-2685
e-ISSN
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Svazek periodika
58
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
9
Strana od-do
377-385
Kód UT WoS článku
000295309700003
EID výsledku v databázi Scopus
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