Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055261" target="_blank" >RIV/00216224:14110/11:00055261 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/11:#0001230

Výsledek na webu

<a href="http://dx.doi.org/10.1097/TA.0b013e3182140c8c" target="_blank" >http://dx.doi.org/10.1097/TA.0b013e3182140c8c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/TA.0b013e3182140c8c" target="_blank" >10.1097/TA.0b013e3182140c8c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children

Popis výsledku v původním jazyce

Backgrounds: Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the central nervous system. It is a brain-specific protein that is released after traumatic brain injury (TBI). Methods: This prospective study enrolled 59 children who had TBI, as verified by computed tomography. Daily GFAP measurement began at admission (&lt; 12 hours after trauma) and continued for 6 days. Blood samples were analyzed for GFAP by enzyme-linked immunosorbent assay. Outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after injury. Results: The median serum levels of GFAP at admission were 7.47 ng/mL in patients who died, compared with 0.12 ng/mL in patients whosurvived (p = 0.002). GFAP levels were significantly higher in patients who had a poor outcome 6 months after injury than in those who were alive or had good outcome (p &lt; 0.001).

Název v anglickém jazyce

Dynamics of Glial Fibrillary Acidic Protein During Traumatic Brain Injury in Children

Popis výsledku anglicky

Backgrounds: Glial fibrillary acidic protein (GFAP) is a monomeric intermediate filament protein found in the astroglial cytoskeleton and is not found outside the central nervous system. It is a brain-specific protein that is released after traumatic brain injury (TBI). Methods: This prospective study enrolled 59 children who had TBI, as verified by computed tomography. Daily GFAP measurement began at admission (&lt; 12 hours after trauma) and continued for 6 days. Blood samples were analyzed for GFAP by enzyme-linked immunosorbent assay. Outcome was assessed using the Glasgow Outcome Scale (GOS) at 6 months after injury. Results: The median serum levels of GFAP at admission were 7.47 ng/mL in patients who died, compared with 0.12 ng/mL in patients whosurvived (p = 0.002). GFAP levels were significantly higher in patients who had a poor outcome 6 months after injury than in those who were alive or had good outcome (p &lt; 0.001).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

The Journal of Trauma: Injury, Infection and Critical Care

ISSN

0022-5282

e-ISSN

—

Svazek periodika

71

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

854-859

Kód UT WoS článku

000295925700020

EID výsledku v databázi Scopus

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