Sperm and embryo analysis of similar t(7;10) translocations transmitted in two families

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00081789" target="_blank" >RIV/00216224:14110/11:00081789 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.fertnstert.2011.04.042" target="_blank" >http://dx.doi.org/10.1016/j.fertnstert.2011.04.042</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fertnstert.2011.04.042" target="_blank" >10.1016/j.fertnstert.2011.04.042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sperm and embryo analysis of similar t(7;10) translocations transmitted in two families

Popis výsledku v původním jazyce

Objective: To compare the sperm meiotic segregation profiles in two men from families with similar t(7;10) translocations and determine the frequency of unbalanced sperm and preimplantation embryos in one couple. Design: Analysis of sperm nuclei and blastomeres by fluorescence in situ hybridization (FISH). Setting: Research institute. Patient(s): Carriers of balanced translocations t(7;10)(q34;q24) and t(7; 10)(q36;q24.3). Intervention(s): Multicolor FISH using probes for chromosomes 7, 10, 8, 18, 21, X, and Y on sperm and preimplantation genetic diagnosis (PGD) of blastomeres. Main Outcome Measure(s): Frequencies of meiotic segregation products in sperm and blastomeres and sperm aneuploidy of chromosomes 8, 18, 21, X, and Y. Result(s): Similar meioticsegregation patterns, with preferential alternate segregation (50.6% in patient P1, 48.1% in P2) followed by adjacent 1, adjacent 2 and 3:1 segregations, were observed in the sperm of the two carriers.

Název v anglickém jazyce

Sperm and embryo analysis of similar t(7;10) translocations transmitted in two families

Popis výsledku anglicky

Objective: To compare the sperm meiotic segregation profiles in two men from families with similar t(7;10) translocations and determine the frequency of unbalanced sperm and preimplantation embryos in one couple. Design: Analysis of sperm nuclei and blastomeres by fluorescence in situ hybridization (FISH). Setting: Research institute. Patient(s): Carriers of balanced translocations t(7;10)(q34;q24) and t(7; 10)(q36;q24.3). Intervention(s): Multicolor FISH using probes for chromosomes 7, 10, 8, 18, 21, X, and Y on sperm and preimplantation genetic diagnosis (PGD) of blastomeres. Main Outcome Measure(s): Frequencies of meiotic segregation products in sperm and blastomeres and sperm aneuploidy of chromosomes 8, 18, 21, X, and Y. Result(s): Similar meioticsegregation patterns, with preferential alternate segregation (50.6% in patient P1, 48.1% in P2) followed by adjacent 1, adjacent 2 and 3:1 segregations, were observed in the sperm of the two carriers.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fertility and Sterility

ISSN

0015-0282

e-ISSN

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Svazek periodika

96

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

"E66"-"E70"

Kód UT WoS článku

000292283000019

EID výsledku v databázi Scopus

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