Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060378" target="_blank" >RIV/00216224:14110/12:00060378 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00159816:_____/12:#0000930 RIV/00159816:_____/12:#0000813
Výsledek na webu
<a href="http://www.springerlink.com/content/km07l108721m1m24/?MUD=MP" target="_blank" >http://www.springerlink.com/content/km07l108721m1m24/?MUD=MP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13353-012-0104-2" target="_blank" >10.1007/s13353-012-0104-2</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis
Popis výsledku v původním jazyce
The impact of three single-nucleotide polymorphisms in eotaxin (SCYA11) gene promoter (- 426C/T and - 384A/G) and first exon (67G/A) and recently described hexanucleotide (GAAGGA)n 10.9 kb upstream on coronary atherosclerosis was investigated. Elective coronary angiography of 1050 consecutive subjects was performed. All patients were genotyped for the three SNPs. In a subset of the first 472 samples, the number of (GAAGGA)n repetitions was determined. For further evaluation, short and long variants weredistinguished; the borderline corresponded with the median value of all alleles: 8 and less repetitions were considered as short sequence, 9 and more repetitions as long. Patients with bronchial asthma or insignificant atherosclerosis were excluded; theremaining group of 933 subjects was further investigated. Patients were grouped according to the form of CAD (ACS vs. stable angina) and the number of diseased vessels.
Název v anglickém jazyce
Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis
Popis výsledku anglicky
The impact of three single-nucleotide polymorphisms in eotaxin (SCYA11) gene promoter (- 426C/T and - 384A/G) and first exon (67G/A) and recently described hexanucleotide (GAAGGA)n 10.9 kb upstream on coronary atherosclerosis was investigated. Elective coronary angiography of 1050 consecutive subjects was performed. All patients were genotyped for the three SNPs. In a subset of the first 472 samples, the number of (GAAGGA)n repetitions was determined. For further evaluation, short and long variants weredistinguished; the borderline corresponded with the median value of all alleles: 8 and less repetitions were considered as short sequence, 9 and more repetitions as long. Patients with bronchial asthma or insignificant atherosclerosis were excluded; theremaining group of 933 subjects was further investigated. Patients were grouped according to the form of CAD (ACS vs. stable angina) and the number of diseased vessels.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: Fakultní nemocnice u sv. Anny v Brně - Mezinárodní centrum klinického výzkumu (FNUSA - ICRC)</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of applied genetics
ISSN
1234-1983
e-ISSN
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Svazek periodika
53
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
8
Strana od-do
271-278
Kód UT WoS článku
000306951400003
EID výsledku v databázi Scopus
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