Positron Emission Tomography and Clinical Predictors of Survival in Primary Extragonadal Germ Cell Tumors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060596" target="_blank" >RIV/00216224:14110/12:00060596 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/12:8426 RIV/00064203:_____/12:8426 RIV/00064190:_____/12:#0000363

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Positron Emission Tomography and Clinical Predictors of Survival in Primary Extragonadal Germ Cell Tumors

Popis výsledku v původním jazyce

Primary extragonadal germ cell tumors (EGTs) are an uncommon malignancy accounting for 2?4% of all germ cell neoplasms in adult males. Their prognosis is worse than that for testicular germ cell tumors because of their relative chemoresistance and frequent presentation with widely disseminated metastases. We have studied the role of fluorodeoxyglucose positron emission tomography (FDG-PET) for outcome prediction of patients with EGTs. Patients and Methods: We have retrospectively analysed 36 men with germ cell tumors originating in the mediastinum or the retroperitoneum. All patients were treated between 1994 and 2010. Negative result of testicular ultrasonographic examination and/or testicular biopsy was required for diagnosis of EGT. Platinum-based systemic therapy was used in all cases, and resectable residual tumor masses were removed surgically. Results: Overall survival at one and three years was 81% (95% confidence interval [CI]: 68?94%) and 55% (CI: 38?71%), respectively.

Název v anglickém jazyce

Positron Emission Tomography and Clinical Predictors of Survival in Primary Extragonadal Germ Cell Tumors

Popis výsledku anglicky

Primary extragonadal germ cell tumors (EGTs) are an uncommon malignancy accounting for 2?4% of all germ cell neoplasms in adult males. Their prognosis is worse than that for testicular germ cell tumors because of their relative chemoresistance and frequent presentation with widely disseminated metastases. We have studied the role of fluorodeoxyglucose positron emission tomography (FDG-PET) for outcome prediction of patients with EGTs. Patients and Methods: We have retrospectively analysed 36 men with germ cell tumors originating in the mediastinum or the retroperitoneum. All patients were treated between 1994 and 2010. Negative result of testicular ultrasonographic examination and/or testicular biopsy was required for diagnosis of EGT. Platinum-based systemic therapy was used in all cases, and resectable residual tumor masses were removed surgically. Results: Overall survival at one and three years was 81% (95% confidence interval [CI]: 68?94%) and 55% (CI: 38?71%), respectively.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

178-183

Kód UT WoS článku

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EID výsledku v databázi Scopus

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