Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062449" target="_blank" >RIV/00216224:14110/12:00062449 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388998:_____/12:00376860

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00249-012-0804-x" target="_blank" >http://dx.doi.org/10.1007/s00249-012-0804-x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00249-012-0804-x" target="_blank" >10.1007/s00249-012-0804-x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte

Popis výsledku v původním jazyce

The t-tubules of mammalian ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell, with restricted diffusion to the bulk extracellular space. The trans-sarcolemmal flux of many ions, including Ca2+, occurs predominantly across the t-tubule membrane and thus into and out of this restricted diffusion space. It appears possible, therefore, that ion concentration changes may occur in the t-tubule lumen, which would alter ion flux across the t-tubule membrane. We have used a computer model of the ventricular myocyte, incorporating a t-tubule compartment and experimentally determined values for diffusion between the t-tubule lumen and bulk extracellular space, and ion fluxes across the t-tubule membrane, toinvestigate this possibility. The results show that influx and efflux of different ion species across the t-tubule membrane are similar, but not equal.

Název v anglickém jazyce

Role of t-tubules in the control of trans-sarcolemmal ion flux and intracellular Ca2+ in a model of the rat cardiac ventricular myocyte

Popis výsledku anglicky

The t-tubules of mammalian ventricular myocytes are invaginations of the surface membrane that form a complex network within the cell, with restricted diffusion to the bulk extracellular space. The trans-sarcolemmal flux of many ions, including Ca2+, occurs predominantly across the t-tubule membrane and thus into and out of this restricted diffusion space. It appears possible, therefore, that ion concentration changes may occur in the t-tubule lumen, which would alter ion flux across the t-tubule membrane. We have used a computer model of the ventricular myocyte, incorporating a t-tubule compartment and experimentally determined values for diffusion between the t-tubule lumen and bulk extracellular space, and ion fluxes across the t-tubule membrane, toinvestigate this possibility. The results show that influx and efflux of different ion species across the t-tubule membrane are similar, but not equal.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Biophysics Journal With Biophysics Letters

ISSN

0175-7571

e-ISSN

—

Svazek periodika

41

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

13

Strana od-do

491-503

Kód UT WoS článku

000304445400001

EID výsledku v databázi Scopus

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