Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062695" target="_blank" >RIV/00216224:14110/12:00062695 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

čeština

Název v původním jazyce

Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

Popis výsledku v původním jazyce

Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based onthese activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role.

Název v anglickém jazyce

Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

Popis výsledku anglicky

Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based onthese activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role.

Druh

O - Ostatní výsledky

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů