Dendritic cells and their role in tumor immunosurveillance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00065766" target="_blank" >RIV/00216224:14110/13:00065766 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1177/1753425912449549" target="_blank" >http://dx.doi.org/10.1177/1753425912449549</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1753425912449549" target="_blank" >10.1177/1753425912449549</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dendritic cells and their role in tumor immunosurveillance

Popis výsledku v původním jazyce

Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the reviewwe discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis.

Název v anglickém jazyce

Dendritic cells and their role in tumor immunosurveillance

Popis výsledku anglicky

Dendritic cells (DCs) comprise a heterogeneous population of cells that play a key role in initiating, directing and regulating adaptive immune responses, including those critically involved in tumor immunosurveillance. As a riposte to the central role of DCs in the generation of antitumor immune responses, tumors have developed various mechanisms which impair the immunostimulatory functions of DCs or even instruct them to actively contribute to tumor growth and progression. In the first part of this review we discuss general aspects of DC biology, including their origin, subtypes, immature and mature states, and functional plasticity which ensures a delicate balance between active immune response and immune tolerance. In the second part of the reviewwe discuss the complex interactions between DCs and the tumor microenvironment, and point out the challenges faced by DCs during the recognition of tumor Ags. We also discuss the role of DCs in tumor angiogenesis and vasculogenesis.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11137" target="_blank" >NT11137: Protinádorová terapie - vakcinace dendritickými buňkami u pacientů s metastázujícím renálním karcinomem. Klinická studie fáze II.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Innate Immunity

ISSN

1753-4259

e-ISSN

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Svazek periodika

19

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

98-111

Kód UT WoS článku

000313592100010

EID výsledku v databázi Scopus

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