Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068267" target="_blank" >RIV/00216224:14110/13:00068267 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16170/13:43872318 RIV/62157124:16810/13:43872318 RIV/62156489:43210/13:00199369
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s11033-012-2408-z" target="_blank" >http://dx.doi.org/10.1007/s11033-012-2408-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11033-012-2408-z" target="_blank" >10.1007/s11033-012-2408-z</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Popis výsledku v původním jazyce
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of insects. IBH is a multifactorial disease with contribution of genetic and environmental factors. Candidate gene association analysis of IBH was performed in a groupof 89 Icelandic horses all born in Iceland and imported to Europe. Horses were classified in IBH-affected and non-affected based on clinical signs and history of recurrent dermatitis, and on the results of an in vitro sulfidoleukotriene (sLT)-release assay with Culicoides nubeculosus and Simulium vittatum extract. Different genetic markers were tested for association with IBH by the Fisher's exact test. The effect of the major histocompatibility complex (MHC) gene region was studied by genotyping fivemicrosatellites spanning the MHC region (COR112, COR113, COR114, UM011 and UMN-JH34-2), and exon 2 polymorphisms of the class II Eqca-DRA gene. Associations with Eqca-DRA and COR113 were identified (p < 0.05).
Název v anglickém jazyce
Major histocompatibility complex and other allergy-related candidate genes associated with insect bite hypersensitivity in Icelandic horses
Popis výsledku anglicky
Insect bite hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of insects. IBH is a multifactorial disease with contribution of genetic and environmental factors. Candidate gene association analysis of IBH was performed in a groupof 89 Icelandic horses all born in Iceland and imported to Europe. Horses were classified in IBH-affected and non-affected based on clinical signs and history of recurrent dermatitis, and on the results of an in vitro sulfidoleukotriene (sLT)-release assay with Culicoides nubeculosus and Simulium vittatum extract. Different genetic markers were tested for association with IBH by the Fisher's exact test. The effect of the major histocompatibility complex (MHC) gene region was studied by genotyping fivemicrosatellites spanning the MHC region (COR112, COR113, COR114, UM011 and UMN-JH34-2), and exon 2 polymorphisms of the class II Eqca-DRA gene. Associations with Eqca-DRA and COR113 were identified (p < 0.05).
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
MOLECULAR BIOLOGY REPORTS
ISSN
0301-4851
e-ISSN
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Svazek periodika
Vol. 40
Číslo periodika v rámci svazku
4
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
8
Strana od-do
3333-3340
Kód UT WoS článku
000316221100062
EID výsledku v databázi Scopus
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