Anemia as a predictor of response to antiviral therapy in chronic hepatitis C

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069218" target="_blank" >RIV/00216224:14110/13:00069218 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/13:10173553 RIV/00064165:_____/13:10173553

Výsledek na webu

<a href="http://dx.doi.org/10.4149/BLL_2013_044" target="_blank" >http://dx.doi.org/10.4149/BLL_2013_044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2013_044" target="_blank" >10.4149/BLL_2013_044</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Anemia as a predictor of response to antiviral therapy in chronic hepatitis C

Popis výsledku v původním jazyce

Background: The standard therapy for chronic HCV infection is the administration of pegylated interferons in combination with ribavirin. Anemia is a dose-dependent side-effect of ribavirin administration. The degree of anemia could be indicative of the individual exposure to ribavirin. Aims: 1) To evaluate the correlation of HGB level decreases at specified time-points with a sustained virological response during the antiviral treatment. 2) To compare these parameters with the virological predictors forresponses. Methods: A retrospective analysis of cohort, which comprised 164 patients treated with standard therapy at a tertiary center in Prague, Czech Republic. Results: We identified several predictive factors for a sustained virological response infemales: baseline HGB level &lt;= 140 g/l (p=0.025), maximum drop from baseline &gt;40 g (p=0.039), and a HGB drop in week 4 &gt;30 g (p=0.044). There was only one predictor identified for males: reaching the lowest HGB level after week 1

Název v anglickém jazyce

Anemia as a predictor of response to antiviral therapy in chronic hepatitis C

Popis výsledku anglicky

Background: The standard therapy for chronic HCV infection is the administration of pegylated interferons in combination with ribavirin. Anemia is a dose-dependent side-effect of ribavirin administration. The degree of anemia could be indicative of the individual exposure to ribavirin. Aims: 1) To evaluate the correlation of HGB level decreases at specified time-points with a sustained virological response during the antiviral treatment. 2) To compare these parameters with the virological predictors forresponses. Methods: A retrospective analysis of cohort, which comprised 164 patients treated with standard therapy at a tertiary center in Prague, Czech Republic. Results: We identified several predictive factors for a sustained virological response infemales: baseline HGB level &lt;= 140 g/l (p=0.025), maximum drop from baseline &gt;40 g (p=0.039), and a HGB drop in week 4 &gt;30 g (p=0.044). There was only one predictor identified for males: reaching the lowest HGB level after week 1

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9412" target="_blank" >NR9412: Role hemoxygenázy v patogenezi jaterního poškození u chronické HCV infekce</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bratislava Medical Journal - Bratislavské lékarske listy

ISSN

0006-9248

e-ISSN

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Svazek periodika

114

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

5

Strana od-do

213-217

Kód UT WoS článku

000318058700006

EID výsledku v databázi Scopus

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