Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00072809" target="_blank" >RIV/00216224:14110/13:00072809 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.5772/55938" target="_blank" >http://dx.doi.org/10.5772/55938</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5772/55938" target="_blank" >10.5772/55938</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies

Popis výsledku v původním jazyce

Clonal plasma cell disorders (PCD) including mostly monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) are characterised by expansion of abnormal (clonal) plasma cells (PCs) producing monoclonal protein (M-protein, MIG).Although multiparametric flow cytometry (MFC) allows identification and characterisation of these neoplastic PCs, this approach is used in routine diagnostics of monoclonal gammopathies (MGs) complementarily, mostly in unusual cases. The technological development of flow cytometry (FC) in connection with new findings reveal the need for MFC in clinical analysis of MGs. The main applications of immunophenotypisation in MGs are (1) differential diagnosis, (2) determining the risk of progression in MGUS and asymptomatic MM (aMM), (3) detection of minimal residual disease in treated patients with MM, and (4) analysis of prognostic and/or predictive markers.

Název v anglickém jazyce

Immunophenotyping in Multiple Myeloma and Others Monoclonal Gammopathies

Popis výsledku anglicky

Clonal plasma cell disorders (PCD) including mostly monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) are characterised by expansion of abnormal (clonal) plasma cells (PCs) producing monoclonal protein (M-protein, MIG).Although multiparametric flow cytometry (MFC) allows identification and characterisation of these neoplastic PCs, this approach is used in routine diagnostics of monoclonal gammopathies (MGs) complementarily, mostly in unusual cases. The technological development of flow cytometry (FC) in connection with new findings reveal the need for MFC in clinical analysis of MGs. The main applications of immunophenotypisation in MGs are (1) differential diagnosis, (2) determining the risk of progression in MGUS and asymptomatic MM (aMM), (3) detection of minimal residual disease in treated patients with MM, and (4) analysis of prognostic and/or predictive markers.

Druh

C - Kapitola v odborné knize

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Multiple Myeloma - A Quick Reflection on the Fast Progress

ISBN

9789535110835

Počet stran výsledku

18

Strana od-do

93-110

Počet stran knihy

326

Název nakladatele

InTech

Místo vydání

Rijeka

Kód UT WoS kapitoly

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