Polymorphism 140A/G in lactotransferrin gene and its association with development of dental caries and gingivitis in children

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00074103" target="_blank" >RIV/00216224:14110/14:00074103 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00061343

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphism 140A/G in lactotransferrin gene and its association with development of dental caries and gingivitis in children

Popis výsledku v původním jazyce

Introduction: Dental caries and periodontal diseases are complex, multifactorial diseases and one of the most common illnesses worldwide. Recent evidence suggests a role of LTF in caries and periodontitis. The aim of this study was determine the frequency of the polymorphism 140A/G in lactotransferrin gene and its association with dental caries and gingivitis in children in Czech population. Material and Methods: School children aged 11 ? 13 years were included in the study (N = 637). The subjects weredivided into two groups: without caries (DMFT = 0) and with caries (DMFT1). The caries affected group was stratified as low (DMFT=1), moderate (2DMFT3) and high (DMFT4) caries experience. The level of gingivitis was rated according to gingival index (GI)and subjects were divided into the groups without (GI = 0) and with (GI1) gingivitis. The LTF rs1126478 (140A/G exon 2, Lys/Arg) genotypes were determined by polymerase-chain reaction (PCR) with restriction analysis by EarI enzyme.

Název v anglickém jazyce

Polymorphism 140A/G in lactotransferrin gene and its association with development of dental caries and gingivitis in children

Popis výsledku anglicky

Introduction: Dental caries and periodontal diseases are complex, multifactorial diseases and one of the most common illnesses worldwide. Recent evidence suggests a role of LTF in caries and periodontitis. The aim of this study was determine the frequency of the polymorphism 140A/G in lactotransferrin gene and its association with dental caries and gingivitis in children in Czech population. Material and Methods: School children aged 11 ? 13 years were included in the study (N = 637). The subjects weredivided into two groups: without caries (DMFT = 0) and with caries (DMFT1). The caries affected group was stratified as low (DMFT=1), moderate (2DMFT3) and high (DMFT4) caries experience. The level of gingivitis was rated according to gingival index (GI)and subjects were divided into the groups without (GI = 0) and with (GI1) gingivitis. The LTF rs1126478 (140A/G exon 2, Lys/Arg) genotypes were determined by polymerase-chain reaction (PCR) with restriction analysis by EarI enzyme.

Druh

O - Ostatní výsledky

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů