Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075216" target="_blank" >RIV/00216224:14110/14:00075216 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s11255-014-0704-3" target="_blank" >http://dx.doi.org/10.1007/s11255-014-0704-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11255-014-0704-3" target="_blank" >10.1007/s11255-014-0704-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer

Popis výsledku v původním jazyce

To evaluate benefits of sentinel lymph node (SLN) biopsy for staging accuracy in prostate cancer. Extended pelvic lymph node dissection (ePLND) is a preferred staging tool; however, it may underestimate the incidence of nodal involvement. Eighty patientswith estimated risk of lymphadenopathy above 5 % based on Briganti nomogram had Tc-99m-labeled nanocolloid injected into the prostate. Planar lymphoscintigraphy and single-photon emission computed tomography/CT were performed to localize SLNs. Radioguided SLN dissection was followed by backup ePLND comprising external iliac, obturator and internal iliac regions. All SLNs were serially sectioned every 150 mu m and examined using hematoxylin and eosin; immunohistochemical staining was applied every 300 mu m. A total of 335 SLNs were detected, and 17 % were located outside ePLND template. Nodal metastases were diagnosed in 32 patients (40 %).

Název v anglickém jazyce

Sentinel lymph node dissection combined with meticulous histology increases the detection rate of nodal metastases in prostate cancer

Popis výsledku anglicky

To evaluate benefits of sentinel lymph node (SLN) biopsy for staging accuracy in prostate cancer. Extended pelvic lymph node dissection (ePLND) is a preferred staging tool; however, it may underestimate the incidence of nodal involvement. Eighty patientswith estimated risk of lymphadenopathy above 5 % based on Briganti nomogram had Tc-99m-labeled nanocolloid injected into the prostate. Planar lymphoscintigraphy and single-photon emission computed tomography/CT were performed to localize SLNs. Radioguided SLN dissection was followed by backup ePLND comprising external iliac, obturator and internal iliac regions. All SLNs were serially sectioned every 150 mu m and examined using hematoxylin and eosin; immunohistochemical staining was applied every 300 mu m. A total of 335 SLNs were detected, and 17 % were located outside ePLND template. Nodal metastases were diagnosed in 32 patients (40 %).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Urology and Nephrology

ISSN

0301-1623

e-ISSN

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Svazek periodika

46

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

1543-1549

Kód UT WoS článku

000340523800012

EID výsledku v databázi Scopus

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