ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075527" target="_blank" >RIV/00216224:14110/14:00075527 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11150/14:10283888 RIV/00179906:_____/14:10283888

Výsledek na webu

<a href="http://dx.doi.org/10.4149/neo_2014_010" target="_blank" >http://dx.doi.org/10.4149/neo_2014_010</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2014_010" target="_blank" >10.4149/neo_2014_010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer

Popis výsledku v původním jazyce

The purpose of our study was to evaluate a possible correlation between genetic polymorphisms in ATM and TGFB1 genes and late toxicity of chemoradiotherapy for locally advanced cervical cancer. Fifty five patients with FIGO stage JIB and higher without adisease recurrence with a mean follow up of 6 years were included. Late toxicity was assessed by EORTC/RTOG late toxicity criteria. Univariate and multivariate logistic regression model was used for statistical analysis. Degree of association between polymorphisms and late toxicity of chemotherapy was assessed on the basis of phi-coefficient (phi) as well. We did not find any association between 5557G&gt;A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity.

Název v anglickém jazyce

ATM and TGFB1 genes polymorphisms in prediction of late complications of chemoradiotherapy in patients with locally advanced cervical cancer

Popis výsledku anglicky

The purpose of our study was to evaluate a possible correlation between genetic polymorphisms in ATM and TGFB1 genes and late toxicity of chemoradiotherapy for locally advanced cervical cancer. Fifty five patients with FIGO stage JIB and higher without adisease recurrence with a mean follow up of 6 years were included. Late toxicity was assessed by EORTC/RTOG late toxicity criteria. Univariate and multivariate logistic regression model was used for statistical analysis. Degree of association between polymorphisms and late toxicity of chemotherapy was assessed on the basis of phi-coefficient (phi) as well. We did not find any association between 5557G&gt;A polymorphism in the ATM gene or single TGFB1 polymorphisms and late toxicity.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NT11334" target="_blank" >NT11334: Genetická predikce pozdní toxicity radioterapie cervikálního karcinomu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

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Svazek periodika

61

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

70-76

Kód UT WoS článku

000329769500010

EID výsledku v databázi Scopus

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