Pathophysiological characterization of drug hypersensitivity to tribenoside

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075892" target="_blank" >RIV/00216224:14110/14:00075892 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/14:00061357

Výsledek na webu

<a href="http://dx.doi.org/10.2478/s11536-013-0248-4" target="_blank" >http://dx.doi.org/10.2478/s11536-013-0248-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11536-013-0248-4" target="_blank" >10.2478/s11536-013-0248-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pathophysiological characterization of drug hypersensitivity to tribenoside

Popis výsledku v původním jazyce

Tribenoside is a semisynthetic sugar derivative that is mainly indicated for treatment of chronic venous insufficiency. Up to 10% of patients treated by tribenoside can suffer from skin side effects. The adverse effects usually present as angioedema, urticaria, or maculopapular exanthema. The pathophysiology of the reaction has not as yet been elucidated. In this study, we examined 22 patients with drug eruptions caused by tribenoside. Patch tests were performed to investigate in vivo cellular reactions. Laboratory investigations were carried out by lymphocyte transformation tests and basophil activation tests. We found a positive patch test reaction to tribenoside in one patient. The lymphocyte transformation test elicited a borderline positive reaction in one patient, and the basophil activation test gave a clearly positive reaction in another patient. The diagnosis of drug hypersensitivity reactions is a challenge.

Název v anglickém jazyce

Pathophysiological characterization of drug hypersensitivity to tribenoside

Popis výsledku anglicky

Tribenoside is a semisynthetic sugar derivative that is mainly indicated for treatment of chronic venous insufficiency. Up to 10% of patients treated by tribenoside can suffer from skin side effects. The adverse effects usually present as angioedema, urticaria, or maculopapular exanthema. The pathophysiology of the reaction has not as yet been elucidated. In this study, we examined 22 patients with drug eruptions caused by tribenoside. Patch tests were performed to investigate in vivo cellular reactions. Laboratory investigations were carried out by lymphocyte transformation tests and basophil activation tests. We found a positive patch test reaction to tribenoside in one patient. The lymphocyte transformation test elicited a borderline positive reaction in one patient, and the basophil activation test gave a clearly positive reaction in another patient. The diagnosis of drug hypersensitivity reactions is a challenge.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Central European Journal of Medicine

ISSN

1895-1058

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

10

Strana od-do

159-168

Kód UT WoS článku

000330986800024

EID výsledku v databázi Scopus

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