Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076660" target="_blank" >RIV/00216224:14110/14:00076660 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00159816:_____/14:00061155
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
Popis výsledku v původním jazyce
Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed asignificant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNE
Název v anglickém jazyce
Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension
Popis výsledku anglicky
Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation < 90% (t90)>/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 >/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed asignificant and independent association of left atrial volume index (LAVI) with t90 >/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNE
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FA - Kardiovaskulární nemoci včetně kardiochirurgie
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Experimental and Clinical Cardiology
ISSN
1205-6626
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
8
Stát vydavatele periodika
CA - Kanada
Počet stran výsledku
14
Strana od-do
3204-3217
Kód UT WoS článku
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EID výsledku v databázi Scopus
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