Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076840" target="_blank" >RIV/00216224:14110/14:00076840 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00209805:_____/14:#0000506 RIV/00216208:11130/14:10293022 RIV/65269705:_____/14:00061783 RIV/00064203:_____/14:10293022

Výsledek na webu

<a href="http://dx.doi.org/10.1159/000357407" target="_blank" >http://dx.doi.org/10.1159/000357407</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000357407" target="_blank" >10.1159/000357407</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation

Popis výsledku v původním jazyce

Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics previously unreported. Patients and Methods: The study group comprised 267 individuals. They were screenedfor the most common variants of low TPMT activity. TPMT activity was measured in erythrocytes using the HPLC rate-blanked method. Results: Thirty-three patients (12.4%) were heterozygous (26 were TPMT*1/*3A, 5 TPMT*1/*2, 2 TPMT*1/*3C) and 1 was a compound heterozygote (*2/*3A). Normal and low normal TPMT activities substantially overlapped in wildtype and heterozygous individuals, whereas high activities were found in 29 wild-type genotyped patients.

Název v anglickém jazyce

Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation

Popis výsledku anglicky

Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics previously unreported. Patients and Methods: The study group comprised 267 individuals. They were screenedfor the most common variants of low TPMT activity. TPMT activity was measured in erythrocytes using the HPLC rate-blanked method. Results: Thirty-three patients (12.4%) were heterozygous (26 were TPMT*1/*3A, 5 TPMT*1/*2, 2 TPMT*1/*3C) and 1 was a compound heterozygote (*2/*3A). Normal and low normal TPMT activities substantially overlapped in wildtype and heterozygous individuals, whereas high activities were found in 29 wild-type genotyped patients.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oncology

ISSN

0030-2414

e-ISSN

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Svazek periodika

86

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

152-158

Kód UT WoS článku

000335939300004

EID výsledku v databázi Scopus

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