Brain tissue oxygen directed management and outcome in the patients with severe traumatic brain injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078322" target="_blank" >RIV/00216224:14110/14:00078322 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/14:00061774

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Brain tissue oxygen directed management and outcome in the patients with severe traumatic brain injury

Popis výsledku v původním jazyce

Secondary damage is leading but often preventable cause of death in severe TBI. ICP control and treatment of CPP have significantly reduced the mortality. The effect of a brain tissue oxygen directed critical care could improve the 6-month GOS in patients with TBI. METHODS: 50 patients underwent prospective evaluation. They were treated in accordance with a PbtO2 values, maintaining brain oxygen level &gt; 20 mm Hg and control ICP &lt; 20 mm Hg. Outcomes were compared with those in a historical patientcohort. RESULTS: 65% of patients had an initially low PbtO2 and comparatively high ICP. Treatment with the PbtO2 directed protocol resulted in a 44% improvement in mean PbtO2 (p &lt; 0.001), control of ICP and the maintenance of CPP. Persistently low cerebral oxygenation was seen in 37% of patients. Thus elevated ICP and a persistent low PbtO2 represented increasing odds of death.

Název v anglickém jazyce

Brain tissue oxygen directed management and outcome in the patients with severe traumatic brain injury

Popis výsledku anglicky

Secondary damage is leading but often preventable cause of death in severe TBI. ICP control and treatment of CPP have significantly reduced the mortality. The effect of a brain tissue oxygen directed critical care could improve the 6-month GOS in patients with TBI. METHODS: 50 patients underwent prospective evaluation. They were treated in accordance with a PbtO2 values, maintaining brain oxygen level &gt; 20 mm Hg and control ICP &lt; 20 mm Hg. Outcomes were compared with those in a historical patientcohort. RESULTS: 65% of patients had an initially low PbtO2 and comparatively high ICP. Treatment with the PbtO2 directed protocol resulted in a 44% improvement in mean PbtO2 (p &lt; 0.001), control of ICP and the maintenance of CPP. Persistently low cerebral oxygenation was seen in 37% of patients. Thus elevated ICP and a persistent low PbtO2 represented increasing odds of death.

Druh

O - Ostatní výsledky

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

—

Projekt

<a href="/cs/project/NT12116" target="_blank" >NT12116: Význam přímého měření oxygenace mozkové tkáně pro cílenou terapii a zlepšení výsledků léčby pacientů s těžkým kraniocerebrálním poraněním.</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů