Escherichia coli strains of phylogenetic group B2 and D and bacteriocin production are associated with advanced colorectal neoplasia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078631" target="_blank" >RIV/00216224:14110/14:00078631 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62690094:18440/14:50003021

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s12879-014-0733-7" target="_blank" >http://dx.doi.org/10.1186/s12879-014-0733-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12879-014-0733-7" target="_blank" >10.1186/s12879-014-0733-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Escherichia coli strains of phylogenetic group B2 and D and bacteriocin production are associated with advanced colorectal neoplasia

Popis výsledku v původním jazyce

Background: Colorectal cancer (CRC) is the 3rd most common cancer worldwide and the Czech Republic has the 6th highest incidence of CRC worldwide. Large intestinal microbiota play in its etiopathogenesis important role. Bacteriocins are proteins, produced by bacteria from the Enterobacteriaceae family. The aim of our prospective study was to assess the colonization of large intestinal mucosa by Escherichia coli strains and to investigate their bacteriocin production. Methods: A total of 30 consecutive patients with colorectal adenoma, CRA (17 men, 13 women, aged 39?79, mean age 63 +/- 9), 30 patients with CRC (23 men, 7 women, aged 38?86, mean age 67 +/- 11) and 20 healthy controls (9 men, 11 women, age 23?84, mean age 55 +/- 15) were enrolled into prospective study. Mucosal biopsies were taken in the caecum, transverse colon and rectum during pancolonoscopy. Microbiological culture, isolation and identification of bacteria followed.

Název v anglickém jazyce

Escherichia coli strains of phylogenetic group B2 and D and bacteriocin production are associated with advanced colorectal neoplasia

Popis výsledku anglicky

Background: Colorectal cancer (CRC) is the 3rd most common cancer worldwide and the Czech Republic has the 6th highest incidence of CRC worldwide. Large intestinal microbiota play in its etiopathogenesis important role. Bacteriocins are proteins, produced by bacteria from the Enterobacteriaceae family. The aim of our prospective study was to assess the colonization of large intestinal mucosa by Escherichia coli strains and to investigate their bacteriocin production. Methods: A total of 30 consecutive patients with colorectal adenoma, CRA (17 men, 13 women, aged 39?79, mean age 63 +/- 9), 30 patients with CRC (23 men, 7 women, aged 38?86, mean age 67 +/- 11) and 20 healthy controls (9 men, 11 women, age 23?84, mean age 55 +/- 15) were enrolled into prospective study. Mucosal biopsies were taken in the caecum, transverse colon and rectum during pancolonoscopy. Microbiological culture, isolation and identification of bacteria followed.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Infectious Diseases

ISSN

1471-2334

e-ISSN

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Svazek periodika

14

Číslo periodika v rámci svazku

733

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

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EID výsledku v databázi Scopus

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