Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082099" target="_blank" >RIV/00216224:14110/15:00082099 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00061496

Výsledek na webu

<a href="http://dx.doi.org/10.5507/bp.2014.043" target="_blank" >http://dx.doi.org/10.5507/bp.2014.043</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5507/bp.2014.043" target="_blank" >10.5507/bp.2014.043</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Popis výsledku v původním jazyce

Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case ?control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restrictionanalysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controlswere found (P &gt; 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01).

Název v anglickém jazyce

Association of polymorphisms in the endocannabinoid system genes with myocardial infarction and plasma cholesterol levels

Popis výsledku anglicky

Aims. The aim of this study was to investigate the relationship between selected symptoms of chronic heart failure (myocardial infarction, plasma cholesterol level) and single nucleotide polymorphisms (SNPs) in the FAAH and CNR1 genes. Methods. A case ?control study involving 155 patients with chronic heart failure and 169 age- and sex-matched healthy subjects. We detected SNPs 385 C/A (rs324420) in the FAAH and 1359 G/A (rs1049353) in the CNR1 genes using the polymerase chain reaction and restrictionanalysis. Genotype and allele frequencies were compared between patients and controls as well as between patients with and without myocardial infarction. Results. No significant differences in genotype or allelic frequencies between patients and controlswere found (P &gt; 0.05). Carriers of the FAAH A allele had a 2.37-fold increase in the risk of myocardial infarction (odds ratio 2.37, 95% confidence interval 1.36-6.93, P = 0.01).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

—

Svazek periodika

159

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

535-539

Kód UT WoS článku

000366566700004

EID výsledku v databázi Scopus

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