Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082189" target="_blank" >RIV/00216224:14110/15:00082189 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/15:43873856 RIV/00159816:_____/15:00063353

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijpharm.2014.11.065" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2014.11.065</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2014.11.065" target="_blank" >10.1016/j.ijpharm.2014.11.065</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Popis výsledku v původním jazyce

Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A?E) and six dosage forms (simple compressed tablets ? T/S; film coated tablets ? T/FC; enteric coated tablets ? T/EC; capsules with powder filling ? C/P; capsules containing extended release pellets ? C/ER; capsules containing gastro-resistant pellets ? C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial lossesassociated with each step of drug administration were also determined. Results: Significant drug losses were measured (4?38%).

Název v anglickém jazyce

Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Popis výsledku anglicky

Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A?E) and six dosage forms (simple compressed tablets ? T/S; film coated tablets ? T/FC; enteric coated tablets ? T/EC; capsules with powder filling ? C/P; capsules containing extended release pellets ? C/ER; capsules containing gastro-resistant pellets ? C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial lossesassociated with each step of drug administration were also determined. Results: Significant drug losses were measured (4?38%).

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LM2013034" target="_blank" >LM2013034: Projekt CZECRIN v rámci budování české části výzkumné infrastruktury pan-evropského významu v rámci Evropského konsorcia pro výzkumnou infrastrukturu (ERIC)</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

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Svazek periodika

478

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

368-371

Kód UT WoS článku

000348621100041

EID výsledku v databázi Scopus

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