Trefoil factor 3 as a marker of intestinal cell damage during sepsis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082863" target="_blank" >RIV/00216224:14110/15:00082863 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/65269705:_____/15:00064084
Výsledek na webu
<a href="http://dx.doi.org/10.1515/med-2015-0020" target="_blank" >http://dx.doi.org/10.1515/med-2015-0020</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/med-2015-0020" target="_blank" >10.1515/med-2015-0020</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Trefoil factor 3 as a marker of intestinal cell damage during sepsis
Popis výsledku v původním jazyce
Objective: Gastrointestinal dysfunction or gut failure frequently occurs in seriously ill patients and can be responsible for multi-organ failure. Trefoil factor 3 (TFF3) was characterized for its role in reconstitution of an epithelial barrier after mucosal injury in the jejunum. The aims of our study was an analysis of TFF3 levels dynamics in patients with sepsis and the correlation of TFF3 with severity of sepsis and mortality. Methods: Prospective observational study, a ten days evaluation period inchildren aged 0-19 years with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of TFF3 were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. Results: Analysisof dynamics revealed steady levels of TFF3 during the 10 day period evaluated. TFF3 levels could not differentiate between various septic conditions in patients until a marked organ dysfunction developed.
Název v anglickém jazyce
Trefoil factor 3 as a marker of intestinal cell damage during sepsis
Popis výsledku anglicky
Objective: Gastrointestinal dysfunction or gut failure frequently occurs in seriously ill patients and can be responsible for multi-organ failure. Trefoil factor 3 (TFF3) was characterized for its role in reconstitution of an epithelial barrier after mucosal injury in the jejunum. The aims of our study was an analysis of TFF3 levels dynamics in patients with sepsis and the correlation of TFF3 with severity of sepsis and mortality. Methods: Prospective observational study, a ten days evaluation period inchildren aged 0-19 years with systemic inflammatory response syndrome or septic state. Blood tests to determine levels of TFF3 were obtained as long as the patient met the criteria for systemic inflammatory response syndrome or sepsis. Results: Analysisof dynamics revealed steady levels of TFF3 during the 10 day period evaluated. TFF3 levels could not differentiate between various septic conditions in patients until a marked organ dysfunction developed.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FG - Pediatrie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Open Medicine
ISSN
2391-5463
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
PL - Polská republika
Počet stran výsledku
6
Strana od-do
261-266
Kód UT WoS článku
000371696900021
EID výsledku v databázi Scopus
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