Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084659" target="_blank" >RIV/00216224:14110/15:00084659 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00159816:_____/15:00063770

Výsledek na webu

<a href="http://dx.doi.org/10.1016/S2213-2600(14)70290-5" target="_blank" >http://dx.doi.org/10.1016/S2213-2600(14)70290-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/S2213-2600(14)70290-5" target="_blank" >10.1016/S2213-2600(14)70290-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Popis výsledku v původním jazyce

Background Sepsis continues to be a major cause of death, disability; and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim ofthis study was to identify genetic variants that influence sepsis survival. Methods We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in ameta-analysis of 1553 patients from all three cohorts, of whom 359 died within 28 days of admission to the intensive-care unit.

Název v anglickém jazyce

Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study

Popis výsledku anglicky

Background Sepsis continues to be a major cause of death, disability; and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim ofthis study was to identify genetic variants that influence sepsis survival. Methods We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in ameta-analysis of 1553 patients from all three cohorts, of whom 359 died within 28 days of admission to the intensive-care unit.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

LANCET RESPIRATORY MEDICINE

ISSN

2213-2600

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

53-60

Kód UT WoS článku

000347365900021

EID výsledku v databázi Scopus

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