Lenalidomide and dexamethasone for acute light chain-induced renal failure: a phase II study
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084781" target="_blank" >RIV/00216224:14110/15:00084781 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/65269705:_____/15:00063432
Výsledek na webu
<a href="http://dx.doi.org/10.3324/haematol.2014.115204" target="_blank" >http://dx.doi.org/10.3324/haematol.2014.115204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2014.115204" target="_blank" >10.3324/haematol.2014.115204</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Lenalidomide and dexamethasone for acute light chain-induced renal failure: a phase II study
Popis výsledku v původním jazyce
We prospectively evaluated the activity and tolerance of lenalidomide- dexamethasone in 35 patients with acute light chain- induced renal failure. The lenalidomide dose was adapted to the estimated glomerular filtration rate and dexamethasone was given at high dose in cycle one and at low dose thereafter. Four patients died within the first two cycles, and five discontinued therapy leaving 26 patients for the per- protocol analysis. Responses were observed in 24/ 35 ( 68.6%) patients of the intent- to-treat population. Complete response was noted in seven patients ( 20%), very good partial response in three patients ( 8.6%), partial response in 14 patients ( 40%), and min-imal response in one patient ( 2.9%). Renal response was observed in 16 ( 45.7%)patients: five ( 14.2%) achieved complete, four ( 11.4%) partial and seven ( 20%) minor renal responses. Five of 13 patients who were dialysis dependent at baseline became dialysis independent.
Název v anglickém jazyce
Lenalidomide and dexamethasone for acute light chain-induced renal failure: a phase II study
Popis výsledku anglicky
We prospectively evaluated the activity and tolerance of lenalidomide- dexamethasone in 35 patients with acute light chain- induced renal failure. The lenalidomide dose was adapted to the estimated glomerular filtration rate and dexamethasone was given at high dose in cycle one and at low dose thereafter. Four patients died within the first two cycles, and five discontinued therapy leaving 26 patients for the per- protocol analysis. Responses were observed in 24/ 35 ( 68.6%) patients of the intent- to-treat population. Complete response was noted in seven patients ( 20%), very good partial response in three patients ( 8.6%), partial response in 14 patients ( 40%), and min-imal response in one patient ( 2.9%). Renal response was observed in 16 ( 45.7%)patients: five ( 14.2%) achieved complete, four ( 11.4%) partial and seven ( 20%) minor renal responses. Five of 13 patients who were dialysis dependent at baseline became dialysis independent.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Haematologica
ISSN
0390-6078
e-ISSN
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Svazek periodika
100
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
IT - Italská republika
Počet stran výsledku
7
Strana od-do
385-391
Kód UT WoS článku
000351279900029
EID výsledku v databázi Scopus
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