Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00092433" target="_blank" >RIV/00216224:14110/15:00092433 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1177/1721727X15618671" target="_blank" >http://dx.doi.org/10.1177/1721727X15618671</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1177/1721727X15618671" target="_blank" >10.1177/1721727X15618671</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation

Popis výsledku v původním jazyce

The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-10 and TGF-beta after single and repeated administration of the drug. To study the effect of a single and repeated dose fluoxetine on carrageenan-induced paw edema male Wistar rats were divided into five groups (n = 8): control group; positive control group; and three experimental groups treated with 5, 10, and 20 mg/kg bodyweight (bw) fluoxetine, respectively. To study the effect of a single and repeated dose of fluoxetine on serum cytokine levels, the animals were divided in four groups (n = 8): two control groups treated with saline and two experimental groups treated with fluoxetine 20 mg/kg bw. Carrageenan and LPS were injected immediately after fluoxetine or saline injection.

Název v anglickém jazyce

Study on anti-inflammatory and immunomodulatory effects of fluoxetine in rat models of inflammation

Popis výsledku anglicky

The aim of the present study was to evaluate the anti-inflammatory effect of fluoxetine in carrageenan- and lipoplysaccharide-induced models of inflammation by investigating the changes in serum levels of pro-inflammatory cytokine TNF-alpha and anti-inflammatory cytokines IL-10 and TGF-beta after single and repeated administration of the drug. To study the effect of a single and repeated dose fluoxetine on carrageenan-induced paw edema male Wistar rats were divided into five groups (n = 8): control group; positive control group; and three experimental groups treated with 5, 10, and 20 mg/kg bodyweight (bw) fluoxetine, respectively. To study the effect of a single and repeated dose of fluoxetine on serum cytokine levels, the animals were divided in four groups (n = 8): two control groups treated with saline and two experimental groups treated with fluoxetine 20 mg/kg bw. Carrageenan and LPS were injected immediately after fluoxetine or saline injection.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Inflammation

ISSN

1721-727X

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

173-182

Kód UT WoS článku

000365744100005

EID výsledku v databázi Scopus

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