Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088129" target="_blank" >RIV/00216224:14110/16:00088129 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00159816:_____/16:00066192
Výsledek na webu
<a href="http://dx.doi.org/10.1002/eji.201670200" target="_blank" >http://dx.doi.org/10.1002/eji.201670200</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eji.201670200" target="_blank" >10.1002/eji.201670200</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
Popis výsledku v původním jazyce
Background: Periodontitis is a chronic inflammatory disease triggered by specific subgingival bacteria. Evidence suggests that diabetes mellitus (DM) may modulate periodontal tissue destruction, e.g. by reducing the polymorphonuclear leukocyte functions, including chemotaxis, adherence and phagocytosis. CXCR2 is a specific receptor for the interleukin-8 (IL-8) that is chemoattractant for neutrophils with an important role in the regulation of inflammatory response. Material and Methods: We analyzed CXCR2 +785C/T (rs2230054), +1208C/T (rs1126579) and +1440A/G (rs1126580) polymorphisms in patients with chronic periodontitis (CP) or CP with type 2 DM (T2DM+CP) and healthy controls and determined their associations with risk of diseases and occurrence of periodontal pathogens. Totally, 575 subjects (170 controls, 325 patients with CP and 80 subjects with T2DM+CP) were genotyped using methods based on polymerase chain reaction (PCR). Bacterial colonization (A. actinomycetemcomitans, P. gingivalis, P.
Název v anglickém jazyce
Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
Popis výsledku anglicky
Background: Periodontitis is a chronic inflammatory disease triggered by specific subgingival bacteria. Evidence suggests that diabetes mellitus (DM) may modulate periodontal tissue destruction, e.g. by reducing the polymorphonuclear leukocyte functions, including chemotaxis, adherence and phagocytosis. CXCR2 is a specific receptor for the interleukin-8 (IL-8) that is chemoattractant for neutrophils with an important role in the regulation of inflammatory response. Material and Methods: We analyzed CXCR2 +785C/T (rs2230054), +1208C/T (rs1126579) and +1440A/G (rs1126580) polymorphisms in patients with chronic periodontitis (CP) or CP with type 2 DM (T2DM+CP) and healthy controls and determined their associations with risk of diseases and occurrence of periodontal pathogens. Totally, 575 subjects (170 controls, 325 patients with CP and 80 subjects with T2DM+CP) were genotyped using methods based on polymerase chain reaction (PCR). Bacterial colonization (A. actinomycetemcomitans, P. gingivalis, P.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GB14-37368G" target="_blank" >GB14-37368G: Centrum orofaciálního vývoje a regenerace</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů