Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088893" target="_blank" >RIV/00216224:14110/16:00088893 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/16:PU126013

Výsledek na webu

<a href="http://dx.doi.org/10.2174/0929867323666160405111543" target="_blank" >http://dx.doi.org/10.2174/0929867323666160405111543</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/0929867323666160405111543" target="_blank" >10.2174/0929867323666160405111543</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis

Popis výsledku v původním jazyce

Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression.

Název v anglickém jazyce

Zinc and Copper Homeostasis in Head and Neck Cancer: Review and Meta-Analysis

Popis výsledku anglicky

Metals are known for playing essential roles in human physiology. Copper and zinc are trace elements closely dependent on one another and are involved in cell proliferation, growth, gene expression, apoptosis and other processes. Their homeostasis is crucial and tightly controlled by a resourceful system of transporters and transport proteins which deliver copper and zinc ions to their target sites. Abnormal zinc and copper homeostasis can be seen in a number of malignancies and also in head and neck cancer. Imbalance in this homeostasis is observed as an elevation or decrease of copper and zinc ions in serum or tissue levels in patients with cancer. In head and neck cancer these altered levels stand out from those of other malignancies which makes them an object of interest and therefore zinc and copper ions might be a good target for further research of head and neck cancer development and progression.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14337" target="_blank" >NT14337: Studium a charakterizace primárních nádorových buněčných linií spinocelulárních karcinomů v oblasti hlavy a krku a jejich maligní potenciál.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Medicinal Chemistry

ISSN

0929-8673

e-ISSN

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Svazek periodika

23

Číslo periodika v rámci svazku

13

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

27

Strana od-do

1304-1330

Kód UT WoS článku

000376451300002

EID výsledku v databázi Scopus

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