Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088907" target="_blank" >RIV/00216224:14110/16:00088907 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1038/mp.2016.89" target="_blank" >http://dx.doi.org/10.1038/mp.2016.89</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/mp.2016.89" target="_blank" >10.1038/mp.2016.89</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Popis výsledku v původním jazyce

Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges.

Název v anglickém jazyce

Modeling psychiatric disorders: from genomic findings to cellular phenotypes

Popis výsledku anglicky

Major programs in psychiatric genetics have identified 4150 risk loci for psychiatric disorders. These loci converge on a small number of functional pathways, which span conventional diagnostic criteria, suggesting a partly common biology underlying schizophrenia, autism and other psychiatric disorders. Nevertheless, the cellular phenotypes that capture the fundamental features of psychiatric disorders have not yet been determined. Recent advances in genetics and stem cell biology offer new prospects for cell-based modeling of psychiatric disorders. The advent of cell reprogramming and induced pluripotent stem cells (iPSC) provides an opportunity to translate genetic findings into patient-specific in vitro models. iPSC technology is less than a decade old but holds great promise for bridging the gaps between patients, genetics and biology. Despite many obvious advantages, iPSC studies still present multiple challenges.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/NV15-31063A" target="_blank" >NV15-31063A: Buněčné markery vedoucí ke specifické léčbě "na míru" schizofrenním pacientům</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Psychiatry

ISSN

1359-4184

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

1167-1179

Kód UT WoS článku

000382328900003

EID výsledku v databázi Scopus

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