Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results

Kód výsledku v IS VaVaI

RIV/00216224:14110/16:00088927 - isvavai.cz

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results

Popis výsledku v původním jazyce

Purpose: To evaluate the safety and efficacy of endoluminal irreversible electroporation (IRE) in biliary tract performed with a balloon catheter in the perihilar region. Material and methods: Endoluminal IRE of the common bile duct was performed in 5 domestic swine using a balloon catheter inserted during laparotomy. IRE catheter consists of 3 electrodes with the length of 1 cm, attached around an inflatable balloon at 120 degrees. IRE was performed with parameters of 50-90 pulses of 1500-2000V delivered between each couple of electrodes. All swine models were slaughtered 3 days after the procedure. Imaging study using MRI and histopathologic follow-up was performed. Results: The balloon insertion and IRE procedure was successful in all porcine models. All animals survived for the designated period of 3 days. Periablation edema in hepatoduodenal ligament and adjacent liver tissue measured on postprocedural MRI ranged from 13 to 40 mm in maximum diameter, 2, 5-18, 7 ml in volumetric assessment.

Název v anglickém jazyce

Irreversible electroporation with endoluminal balloon catheterin perihilar region: preliminary results

Popis výsledku anglicky

Purpose: To evaluate the safety and efficacy of endoluminal irreversible electroporation (IRE) in biliary tract performed with a balloon catheter in the perihilar region. Material and methods: Endoluminal IRE of the common bile duct was performed in 5 domestic swine using a balloon catheter inserted during laparotomy. IRE catheter consists of 3 electrodes with the length of 1 cm, attached around an inflatable balloon at 120 degrees. IRE was performed with parameters of 50-90 pulses of 1500-2000V delivered between each couple of electrodes. All swine models were slaughtered 3 days after the procedure. Imaging study using MRI and histopathologic follow-up was performed. Results: The balloon insertion and IRE procedure was successful in all porcine models. All animals survived for the designated period of 3 days. Periablation edema in hepatoduodenal ligament and adjacent liver tissue measured on postprocedural MRI ranged from 13 to 40 mm in maximum diameter, 2, 5-18, 7 ml in volumetric assessment.

Druh

O - Ostatní výsledky

CEP obor

FP - Ostatní lékařské obory

OECD FORD obor

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Projekt

NV15-32484A: Využití nových biotechnologií v prevenci a léčbě stenóz žlučových cest

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů