Cellular reactions of the choroid plexus induced by peripheral nerve injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00090251" target="_blank" >RIV/00216224:14110/16:00090251 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.neulet.2016.06.019" target="_blank" >http://dx.doi.org/10.1016/j.neulet.2016.06.019</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neulet.2016.06.019" target="_blank" >10.1016/j.neulet.2016.06.019</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cellular reactions of the choroid plexus induced by peripheral nerve injury

Popis výsledku v původním jazyce

The choroid plexus (CP) of brain ventricles forms the blood-cerebrospinal fluid (blood-CSF) barrier that is involved in many diseases affecting the central nervous system (CNS). We used ED1 and ED2 immunostaining to investigate epiplexus cell changes in rat CP after chronic constriction injury (CCI). In contrast to naive CP, the CP of sham-operated rats showed an increase in the number of ED1+ cells of a similar magnitude during all periods of survival up to 3 weeks, while the number of ED2+ increased only at 3 days from operation. In comparison to naive and sham-operated animals, the number of ED1+ and ED2+ cells in the epiplexus position increased with the duration of nerve compression. We detected no or negligible cell proliferation in the CP after sham- or CCI-operation. This suggests that increased number of ED1+ and ED2+ cells in the epiplexus position of the CP is derived from peripheral monocytes passing through altered blood-CSF barrier.

Název v anglickém jazyce

Cellular reactions of the choroid plexus induced by peripheral nerve injury

Popis výsledku anglicky

The choroid plexus (CP) of brain ventricles forms the blood-cerebrospinal fluid (blood-CSF) barrier that is involved in many diseases affecting the central nervous system (CNS). We used ED1 and ED2 immunostaining to investigate epiplexus cell changes in rat CP after chronic constriction injury (CCI). In contrast to naive CP, the CP of sham-operated rats showed an increase in the number of ED1+ cells of a similar magnitude during all periods of survival up to 3 weeks, while the number of ED2+ increased only at 3 days from operation. In comparison to naive and sham-operated animals, the number of ED1+ and ED2+ cells in the epiplexus position increased with the duration of nerve compression. We detected no or negligible cell proliferation in the CP after sham- or CCI-operation. This suggests that increased number of ED1+ and ED2+ cells in the epiplexus position of the CP is derived from peripheral monocytes passing through altered blood-CSF barrier.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroscience Letters

ISSN

0304-3940

e-ISSN

—

Svazek periodika

628

Číslo periodika v rámci svazku

"neuvedeno"

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

5

Strana od-do

73-77

Kód UT WoS článku

000381590800012

EID výsledku v databázi Scopus

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