Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00092308" target="_blank" >RIV/00216224:14110/16:00092308 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1183/13993003.congress-2016.PA1849" target="_blank" >http://dx.doi.org/10.1183/13993003.congress-2016.PA1849</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/13993003.congress-2016.PA1849" target="_blank" >10.1183/13993003.congress-2016.PA1849</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project
Popis výsledku v původním jazyce
Chronic obstructive pulmonary disease (COPD) is linked to increased oxidative and nitrative stress (RNOS) in the airways and systemic circulation. RNOS causes damage of fosfolipids and proteins in cellular membrane including airway epithelium. Exhaled breath analysis (EBC) can reflex intensity of RNOS in COPD. We compared concentration of RNOS biomarkers and anti-inflammatory lipoxin A4 (LXA4) in EBC in COPD patients and healthy controls before and after incremental shuttle walk test (ISWT), actigraphy was used to follow average daily steps 1 week before ISWT. In 29 patents with severe COPD (age 62±1,7, FEV1 48,8 ± 15,6%) and 17 age matched healthy controls were during 1 day performed EBC collection, EBC samples were frozen and analyzed by mass spectrometry with liqid chromatography. After EBC sampling subjects underwent ISWT, and then again gave EBC.
Název v anglickém jazyce
Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project
Popis výsledku anglicky
Chronic obstructive pulmonary disease (COPD) is linked to increased oxidative and nitrative stress (RNOS) in the airways and systemic circulation. RNOS causes damage of fosfolipids and proteins in cellular membrane including airway epithelium. Exhaled breath analysis (EBC) can reflex intensity of RNOS in COPD. We compared concentration of RNOS biomarkers and anti-inflammatory lipoxin A4 (LXA4) in EBC in COPD patients and healthy controls before and after incremental shuttle walk test (ISWT), actigraphy was used to follow average daily steps 1 week before ISWT. In 29 patents with severe COPD (age 62±1,7, FEV1 48,8 ± 15,6%) and 17 age matched healthy controls were during 1 day performed EBC collection, EBC samples were frozen and analyzed by mass spectrometry with liqid chromatography. After EBC sampling subjects underwent ISWT, and then again gave EBC.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FC - Pneumologie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2016
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů