Circulating microparticles as predictor of thrombotic events in BCR/ABL negative myeloproliferative disorders

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Circulating microparticles as predictor of thrombotic events in BCR/ABL negative myeloproliferative disorders

Popis výsledku v původním jazyce

The clinical course of BCR/ABL negative myeloproliferative disorders (MPNs) is frequently complicated by thrombotic events. Microparticles (MPs) are membrane fragments with diameter of 0.1 to 1 microm, which are released by most cell types during their activation or apoptosis. The level of microparticles is known to be elevated in thromboembolic diseases and malignancies. Objective: The aim of this work is to describe the contribution of platelet MPs level and their procoagulant activity to the occurrence of thrombotic complication in patients with BCR/ABL negative MPNs. Methods: The cohort of 121 patients with MPNs (73 males, 48 females) includes 76 patients with essential thrombocythemia, 25 polycythemia vera and 20 primary myelofibrosis. In this cohort was analysed the level of platelet MPs by using flowcytometry and procoagulation activity of MPs by using functional assay (Zymuphen MP-activity kit, Hyphen BioMed). The normal range was confirmed by examination of healthy individuals.

Název v anglickém jazyce

Circulating microparticles as predictor of thrombotic events in BCR/ABL negative myeloproliferative disorders

Popis výsledku anglicky

The clinical course of BCR/ABL negative myeloproliferative disorders (MPNs) is frequently complicated by thrombotic events. Microparticles (MPs) are membrane fragments with diameter of 0.1 to 1 microm, which are released by most cell types during their activation or apoptosis. The level of microparticles is known to be elevated in thromboembolic diseases and malignancies. Objective: The aim of this work is to describe the contribution of platelet MPs level and their procoagulant activity to the occurrence of thrombotic complication in patients with BCR/ABL negative MPNs. Methods: The cohort of 121 patients with MPNs (73 males, 48 females) includes 76 patients with essential thrombocythemia, 25 polycythemia vera and 20 primary myelofibrosis. In this cohort was analysed the level of platelet MPs by using flowcytometry and procoagulation activity of MPs by using functional assay (Zymuphen MP-activity kit, Hyphen BioMed). The normal range was confirmed by examination of healthy individuals.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů