No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00093761" target="_blank" >RIV/00216224:14110/16:00093761 - isvavai.cz</a>

Výsledek na webu

<a href="https://oatext.com/pdf/GOD-3-175.pdf" target="_blank" >https://oatext.com/pdf/GOD-3-175.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15761/GOD.1000175" target="_blank" >10.15761/GOD.1000175</a>

Jazyk výsledku

angličtina

Název v původním jazyce

No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Popis výsledku v původním jazyce

Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms(SNPs) within miRNA genes or 3’UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease. Assess SNP rs1048261 within the 3’UTR of HSPB7 in a large cohort (n=558) of psoriatic patients of Central European Caucasian origin and evaluate its possible role in the increased risk of cardiovascular disease (CVD) in psoriasis patients. This study included 558 patients diagnosed with psoriasis; 30% of the patients had a personal history of CVD. In silico analysis was used to determine a candidate SNP which is associated with a potential impairment of miRNA-mediated translational regulation.

Název v anglickém jazyce

No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Popis výsledku anglicky

Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms(SNPs) within miRNA genes or 3’UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease. Assess SNP rs1048261 within the 3’UTR of HSPB7 in a large cohort (n=558) of psoriatic patients of Central European Caucasian origin and evaluate its possible role in the increased risk of cardiovascular disease (CVD) in psoriasis patients. This study included 558 patients diagnosed with psoriasis; 30% of the patients had a personal history of CVD. In silico analysis was used to determine a candidate SNP which is associated with a potential impairment of miRNA-mediated translational regulation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FO - Dermatovenerologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Global Dermatology

ISSN

2056-7863

e-ISSN

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Svazek periodika

3

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

5

Strana od-do

281-285

Kód UT WoS článku

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EID výsledku v databázi Scopus

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