Progress in human pluripotent stem cell-based modeling systems for neurological diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F17%3A00098812" target="_blank" >RIV/00216224:14110/17:00098812 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1080/23262133.2017.1324258" target="_blank" >http://dx.doi.org/10.1080/23262133.2017.1324258</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/23262133.2017.1324258" target="_blank" >10.1080/23262133.2017.1324258</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Progress in human pluripotent stem cell-based modeling systems for neurological diseases
Popis výsledku v původním jazyce
Human pluripotent stem cell (hPSC)-based modeling offers the potential for studying human diseases using human systems. An increasing number of studies in numerous fields demonstrate that hPSC-based disease systems capture disease specific pathophysiology occurring in vivo. A widespread deployment of hPSC systems is foreseeable. Even the field of psychiatric disorders (for example, schizophrenia and autism), which lags behind due to complex underlying causes, such as the inaccessibility of brain cells for assessments and the absence of reliable models, has been embracing the hPSC-based disease system. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. Our recent study demonstrated that the hPSC-based system mimicked the process of neural development and the system reserved neural stem cell (NSC) niches similar to those residing in the ventricular region of the cortex. In this article, we will first comment on an array of factors that affect hPSC-based neural differentiation and summarize the intricate regulatory signaling pathways that regionalize neuronal cell types. Finally, we review successful studies in brain-related diseases using hPSC-based modeling with 3-D systems.
Název v anglickém jazyce
Progress in human pluripotent stem cell-based modeling systems for neurological diseases
Popis výsledku anglicky
Human pluripotent stem cell (hPSC)-based modeling offers the potential for studying human diseases using human systems. An increasing number of studies in numerous fields demonstrate that hPSC-based disease systems capture disease specific pathophysiology occurring in vivo. A widespread deployment of hPSC systems is foreseeable. Even the field of psychiatric disorders (for example, schizophrenia and autism), which lags behind due to complex underlying causes, such as the inaccessibility of brain cells for assessments and the absence of reliable models, has been embracing the hPSC-based disease system. However, despite hPSCs holding great potential, it is imperative to validate how faithful hPSC-based neural developmental modeling is in recapitulating the developmental process in vivo. Our recent study demonstrated that the hPSC-based system mimicked the process of neural development and the system reserved neural stem cell (NSC) niches similar to those residing in the ventricular region of the cortex. In this article, we will first comment on an array of factors that affect hPSC-based neural differentiation and summarize the intricate regulatory signaling pathways that regionalize neuronal cell types. Finally, we review successful studies in brain-related diseases using hPSC-based modeling with 3-D systems.
Klasifikace
Druh
J<sub>ost</sub> - Ostatní články v recenzovaných periodicích
CEP obor
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OECD FORD obor
10600 - Biological sciences
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Neurogenesis
ISSN
2326-2133
e-ISSN
—
Svazek periodika
4
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
„e1324258-1“-„e1324258-6“
Kód UT WoS článku
—
EID výsledku v databázi Scopus
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