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Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00100920" target="_blank" >RIV/00216224:14110/18:00100920 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/18:10376687 RIV/00159816:_____/18:00068580 RIV/00064165:_____/18:10376687

  • Výsledek na webu

    <a href="http://dx.doi.org/10.1111/jop.12694" target="_blank" >http://dx.doi.org/10.1111/jop.12694</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/jop.12694" target="_blank" >10.1111/jop.12694</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

  • Popis výsledku v původním jazyce

    Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr &lt; .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.

  • Název v anglickém jazyce

    Association of the NOD-like receptor 3 (NLRP3) gene variability with recurrent aphthous stomatitis in the Czech population

  • Popis výsledku anglicky

    Background: Recurrent aphthous stomatitis (RAS) is a multifactorial disease with unclear etiopathogenesis in which disturbance of immunological processes may be involved. The aim of our study was to investigate three single nucleotide polymor- phisms (SNPs) rs3806265, rs4612666, rs10754558 in NOD-like receptor 3 (NLRP3 ), the gene encoding the component of inflammasome, in patients with RAS and healthy controls in the Czech population. Methods: A total of 207 subjects were included in this case-control study. Sixty- four patients with RAS and 143 healthy controls were genotyped by a method based on polymerase chain reaction using 5 0 nuclease TaqMan â assays. Detailed anamnestic, clinical, and laboratory data were obtained from all subjects. Results: The allele and genotype frequencies of NLRP3 polymorphisms (rs10754558 and rs3806265) between both groups were similar. However, statistically significant differences in NLRP3 rs4612666 genotypes between the patients with RAS and controls were found; carriers of the TT genotype had a higher risk of developing RAS than subjects with the CT+CC genotypes (OR = 14.69, 95%CI = 1.73-124.72, P = .004, P corr &lt; .05). No associations between NLRP3 haplotypes and RAS were observed. Conclusions: Our study indicates that the NLRP3 rs4612666 polymorphism may be involved in the development of RAS in the Czech population.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30208 - Dentistry, oral surgery and medicine

Návaznosti výsledku

  • Projekt

    Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2018

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of Oral Pathology & Medicine

  • ISSN

    0904-2512

  • e-ISSN

    1600-0714

  • Svazek periodika

    47

  • Číslo periodika v rámci svazku

    4

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    6

  • Strana od-do

    434-439

  • Kód UT WoS článku

    000430125800016

  • EID výsledku v databázi Scopus

    2-s2.0-85042632552