Recurrent aphthous stomatitis and gene variability in selected interleukins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00101193" target="_blank" >RIV/00216224:14110/18:00101193 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Recurrent aphthous stomatitis and gene variability in selected interleukins

Popis výsledku v původním jazyce

Genetic factors, especially those related to the immune system functioning, have been intensively studied for their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukins (ILs): IL-2, IL-4 and its receptor alpha (IL-4R alpha), IL-10 and IL-13, which were selected based on the literature review and/or their functional relevance, in Czech patients with RAS and healthy controls. Generally, 252 subjects were enrolled in this case-control study (178 controls and 74 patients with RAS) and their detail anamnestic, clinical and laboratory data were obtained. Nine polymorphisms in the genes encoding ILs were determined by PCR techniques. There were no significant differences in allele or genotype frequencies of the studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4 (rs2243250 and rs79071878), IL-4R alpha (rs1801275), IL-10 (rs1800896), and IL-13 (rs1800925) between the controls and RAS patients. The minority alleles of the IL-10 (rs1800871 and rs1800872) variants were associated with a higher risk of RAS , as confirmed by the results of genotype and haplotype analysis. We suggest that variability in the IL-10 gene may play an important role in the RAS development in the Czech population.

Název v anglickém jazyce

Recurrent aphthous stomatitis and gene variability in selected interleukins

Popis výsledku anglicky

Genetic factors, especially those related to the immune system functioning, have been intensively studied for their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukins (ILs): IL-2, IL-4 and its receptor alpha (IL-4R alpha), IL-10 and IL-13, which were selected based on the literature review and/or their functional relevance, in Czech patients with RAS and healthy controls. Generally, 252 subjects were enrolled in this case-control study (178 controls and 74 patients with RAS) and their detail anamnestic, clinical and laboratory data were obtained. Nine polymorphisms in the genes encoding ILs were determined by PCR techniques. There were no significant differences in allele or genotype frequencies of the studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4 (rs2243250 and rs79071878), IL-4R alpha (rs1801275), IL-10 (rs1800896), and IL-13 (rs1800925) between the controls and RAS patients. The minority alleles of the IL-10 (rs1800871 and rs1800872) variants were associated with a higher risk of RAS , as confirmed by the results of genotype and haplotype analysis. We suggest that variability in the IL-10 gene may play an important role in the RAS development in the Czech population.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30208 - Dentistry, oral surgery and medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů